Literature review as part of the annual PMCF (Post-Market Clinical Follow-up) report on the LuXXaMed microcurrent systems
Search strategy: keyword search
Software: Citavi
Databases/catalogues: PubMed, National Library of Medicine, Springer e-book collection, German National Library
Keywords: microcurrent, microcurrent therapy
Time period: 2023–2024
Research literature from 2023–2024 on microcurrent therapy
The latest scientific findings on microcurrent therapy highlight its broad range of applications and demonstrate significant therapeutic benefits across various medical fields. Studies from 2023 and 2024 show that microcurrent not only possesses anti-inflammatory and wound-healing properties, but also contributes to improved quality of life and functional recovery.
The inhibition of IL-1β-induced inflammatory responses and the protection of cartilage tissue in osteoarthritis are notable findings that underline the potential benefits of microcurrent stimulation in the treatment of degenerative joint diseases. Furthermore, wound healing is significantly accelerated by microcurrent-assisted transdermal penetration and re-epithelialisation in skin wounds, opening up new possibilities in wound care.
Microcurrent therapy is also showing promising results in the field of aesthetic rehabilitation by promoting well-being beyond mere functional recovery. The study on the relationship between body mass index and the healing of pressure ulcers using microcurrent demonstrates further nuanced applications of this technology.
In addition, transpalpebral electrical stimulation is being investigated as an innovative treatment method for retinitis pigmentosa, whilst microcurrent therapy is showing positive results as a non-pharmacological protocol for Alzheimer’s disease. The reduction of dental plaque in orthodontic patients using microcurrent toothbrushes and the improved regeneration of peripheral nerve injuries through continuous microcurrent stimulation are also promising approaches.
The combination of microcurrent stimulation and sound therapy for the relief of tinnitus, as well as the role of microcurrent stimulation in bioelectrical medicine, illustrate the broad spectrum of applications and the versatile therapeutic possibilities. Overall, these studies confirm the effectiveness and safety of microcurrent therapy and support its use in modern medical practice.
Another noteworthy aspect is the modulation of myofibroblasts by microcurrent, which contributes significantly to the repair and regeneration of the heart. These findings expand the potential cardiovascular applications of microcurrent therapy.
The use of non-invasive neuromodulation in children with neurodevelopmental disorders shows an improvement in sleep quality and a reduction in constipation, indicating the broad applicability of microcurrent therapy in paediatric neurology.
In the field of cosmetic dermatology, home-use devices for facial rejuvenation have been developed and their efficacy confirmed in clinical trials. These devices offer a new, effective method for improving skin health and aesthetics.
A biomimetic nanogenerator designed to enhance bone regeneration by restoring electrical microenvironments is also showing promising results and could play an important role in orthopaedic rehabilitation in the future.
Overall, it is evident that microcurrent therapy is a versatile and effective tool that can be used in various medical and aesthetic applications. Ongoing research and development in this field will certainly help to further improve the potential applications and efficiency of microcurrent therapy.
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Studies 2023–2024: Microcurrent therapy
Micro-current Stimulation Could Inhibit IL-1β-induced Inflammatory Responses in Chondrocytes and Protect Knee Bone Cartilage from Osteoarthritis
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Authors: Lee, Minjoo; Lee, Hana; Chung, Halim; Lee, Jin-Ho; Kim, Doyong; Cho, Seungkwan; Kim, Tack-Joong; Kim, Han Sung
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Year: 2024
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Journal: Biomedical Engineering Letters
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Results: Microcurrent stimulation can inhibit IL-1β-induced inflammatory responses in chondrocytes and protect knee joint cartilage from osteoarthritis.
Microcurrent Cloth-Assisted Transdermal Penetration and Follicular Duct Escape of Curcumin-Loaded Micelles for Enhanced Wound Healing
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Authors: Lee, Pei-Chi; Li, Cun-Zhao; Lu, Chun-Te; Zhao, Min-Han; Lai, Syu-Ming; Liao, Man-Hua; Peng, Cheng-Liang; Liu, Hsin-Tung; Lai, Ping-Shan
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Year: 2023
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Journal: International Journal of Nanomedicine
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Results: Microcurrent-assisted transdermal penetration and follicular duct escape of curcumin-loaded micelles enhance wound healing.
Automated Electrical Stimulation Therapy Accelerates Re-Epithelialisation in a Three-Dimensional In Vitro Human Skin Wound Model
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Authors: Lim, Priscilla L. K.; Balakrishnan, Yamini; Goh, Gracia; Tham, Khek-Chian; Ng, Yi Zhen; Lunny, Declan P.; Leavesley, David I.; Bonnard, Carine
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Year: 2024
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Journal: Advances in Wound Care
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Results: Automated electrical stimulation therapy accelerates re-epithelialisation in a three-dimensional in vitro model of human skin wounds.
Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery
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Authors: Lippi, Lorenzo; Ferrillo, Martina; Losco, Luigi; Folli, Arianna; Marcasciano, Marco; Curci, Claudio; Moalli, Stefano; Ammendolia, Antonio; Sire, Alessandro de; Invernizzi, Marco
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Year: 2024
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Journal: Medicina (Kaunas, Lithuania)
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Results: Aesthetic rehabilitation therapies using microcurrent promote wellbeing beyond functional recovery.
Association between Patients’ Body Mass Index and the Effect of Monophasic Pulsed Microcurrent Stimulation on Pressure Injury Healing
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Authors: Yoshikawa, Yoshiyuki; Maeshige, Noriaki; Yamaguchi, Atomu; Uemura, Mikiko; Hiramatsu, Terutaka; Tsuji, Yoriko; Terashi, Hiroto
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Year: 2023
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Journal: Biomedicines
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Results: The study investigates the relationship between patients’ body mass index and the effect of monophasic pulsed microcurrent stimulation on the healing of pressure ulcers.
Transpalpebral Electrical Stimulation for the Treatment of Retinitis Pigmentosa: Study Protocol for a Series of N-of-1 Single-blind, Randomised Controlled Trials
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Authors: Zhou, Wei; Huang, Ziyang; Xu, Kai; Li, Yamin; Li, Xiaoyu; Li, Jiaxian; Jin, Yu; Snellingen, Torkel; Liang, Lina
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Year: 2024
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Journal: Trials
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Results: Transpalpebral electrical stimulation is being investigated as a treatment for retinitis pigmentosa. The study describes the protocol for a series of N-of-1
Microcurrent Therapy as a New Non-Pharmacological Protocol for Alzheimer’s Disease
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Authors: Kim, Eun Ho; Lee, Won Seok; Lee, Jae Hee; Kwon, Dong Rak
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Year: 2024
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Journal: Frontiers in Aging Neuroscience
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Results: Microcurrent therapy is being investigated as a new non-pharmacological protocol for Alzheimer’s disease and is showing promising results.
Evaluation of Dental Plaque Reduction Using Microcurrent-emitting Toothbrushes in Orthodontic Patients: A Randomised, Double-blind, Crossover Clinical Trial
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Authors: Kim, Ji-Hoi; Yu, Jae-Hun; Mangal, Utkarsh; Liu, Jing; Jung, Hyo-Jung; Cha, Jung-Yul
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Year: 2024
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Journal: Scientific Reports
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Results: The use of toothbrushes with microcurrent technology effectively reduces dental plaque in orthodontic patients.
Enhancing Regeneration and Repair of Long-distance Peripheral Nerve Defect Injuries with Continuous Microcurrent Electrical Nerve Stimulation
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Authors: Kong, Junjie; Teng, Cheng; Liu, Fenglan; Wang, Xuzhaoyu; Zhou, Yi; Zong, Ying; Wan, Zixin; Qin, Jun; Yu, Bin; Mi, Daguo; Wang, Yaxian
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Year: 2024
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Journal: Frontiers in Neuroscience
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Results: Continuous microcurrent nerve stimulation improves the regeneration and repair of long-distance peripheral nerve defects.
Developing and Testing an Arduino-based Microcurrent Stimulator to Mimic Marine Electric Pollution on Benthos
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Authors: Lattanzi, Davide; Pagliarini, Marica; Rebecchi, Federica; Frontalini, Fabrizio; Ambrogini, Patrizia
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Year: 2024
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Journal: Heliyon
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Results: Development and testing of an Arduino-based microcurrent stimulator to mimic marine electrical pollution on benthos.
The Effectiveness of Microcurrent Stimulation Combined with Sound Therapy for Tinnitus Relief: A Preliminary Study
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Authors: Lee, Donghyeok; Jeong, Youngchan; Lee, Sumin; Jin, Tae-Jun; Jin, In-Ki
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Year: 2024
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Journal: Audiology Research
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Results: Microcurrent stimulation combined with sound therapy shows promising results in the relief of tinnitus.
Bioelectric Medicine: Unveiling the Therapeutic Potential of Microcurrent Stimulation
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Authors: Lee, Hana; Cho, Seungkwan; Kim, Doyong; Lee, Taehyun; Kim, Han Sung
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Year: 2024
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Journal: Biomedical Engineering Letters
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Results: The study highlights the therapeutic potential of microcurrent stimulation in bioelectric medicine.
Microcurrent Wave Alleviates the Development of Intracranial Arterial Dolichoectasia in Mice
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Authors: Lee, Jae Hee; Vu, Huy Duc; Park, Min Hee; Huynh, Phuong Tu; Youn, Sung Won; Kwon, Dong Rak
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Year: 2024
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Journal: Scientific Reports
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Results: Microcurrent waves mitigate the development of intracranial arterial dolichoectasia in mice.
Effects of Cranial Electrotherapy Stimulation on Improving Depressive Symptoms in People with Stress: A Randomised, Double-blind Controlled Study
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Authors: Lee, Minji; Kim, Yuna; Yoon, In-Young; Hong, Jung Kyung
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Year: 2023
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Journal: Journal of Affective Disorders
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Results: Cranial electrotherapy stimulation improves depressive symptoms in people experiencing stress.
Micro-current stimulation could inhibit IL-1β-induced inflammatory responses in chondrocytes and protect knee bone cartilage from osteoarthritis
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Authors: Lee, Minjoo; Lee, Hana; Chung, Halim; Lee, Jin-Ho; Kim, Doyong; Cho, Seungkwan; Kim, Tack-Joong; Kim, Han Sung
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Year: 2024
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Journal: Biomedical Engineering Letters
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Results: Microcurrent stimulation can inhibit IL-1β-induced inflammatory responses in chondrocytes and protect knee joint cartilage from osteoarthritis.
Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration
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Authors: Bachamanda Somesh, Dipthi; Jürchott, Karsten; Giesel, Thomas; Töllner, Thomas; Prehn, Alexander; Richters, Jan-Peter; Kosevic, Dragana; Eduardo Rame, Jesus; Göttel, Peter; Müller, Johannes
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Year: 2024
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Journal: International Journal of Molecular Sciences
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Results: The study shows that microcurrent promotes the modulation of myofibroblasts, which contributes to cardiac repair and regeneration.
Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
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Authors: Báez-Suárez, Aníbal; Padrón-Rodríguez, Iraya; Castellano-Moreno, Elizabeth; González-González, Erica; Quintana-Montesdeoca, María P.; Medina-Ramirez, Raquel Irina
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Year: 2023
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Journal: BMC Pediatrics
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Results: The use of non-invasive neuromodulation improves sleep quality and reduces constipation in children with neurodevelopmental disorders.
Development of Home Beauty Devices for Facial Rejuvenation: Establishment of an Efficacy Evaluation System
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Authors: Bu, Pengzhi; Duan, Ruqian; Luo, Ji; Yang, Tao; Liu, Ning; Wen, Chuanbiao
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Year: 2024
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Journal: Clinical, Cosmetic and Investigational Dermatology
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Results: The study describes the development of home-use devices for facial rejuvenation and presents a system for evaluating their efficacy.
A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments
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Authors: Chen, Yiyi; Chen, Yuhong; Xie, Zhe; Yang, Yuchen; Chen, Siyuan; Han, Tianlei; Li, Miaomiao; Guo, Zhengnong; Sun, Nuo; Wang, Chen
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Year: 2024
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Journal: ACS Biomaterials Science & Engineering
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Results: A biomimetic nanogenerator enhances bone regeneration by restoring electrical microenvironments.
Efficacy and safety of a home-use handheld multi-energy-based device for skin rejuvenation: clinical, ex vivo, and histological studies
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Authors: Choi, Sooyeon; Kim, Jemin; Lee, Young-in; Lee, Sang-gyu; Jung, In-hee; Suk, Jang-mi; Lee, Ju-hee
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Year: 2024
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Journal: Lasers in Medical Science
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Results: The efficacy and safety of a home-use device for skin rejuvenation were demonstrated in clinical, ex vivo and histological studies.
The effectiveness of microcurrent neurofeedback on depression, anxiety, post-traumatic stress disorder, and quality of life
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Authors: Duke, Gloria; Yotter, Courtney N.; Sharifian, Beverly; Duke, Gary; Petersen, Sandra
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Year: 2024
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Journal: Journal of the American Association of Nurse Practitioners
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Results: Microcurrent neurofeedback has been shown to have positive effects on depression, anxiety, post-traumatic stress disorder and quality of life.
The Effect of Varied Time Interval and Micro-Current (Direct) on the Level of Biomarker (IL-6) and Rate of Tooth Movement: An Animal Study
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Authors: Dwivedi, Parnita; Agrawal, Ashish; Gupta, Subash Chandra; Chou, Tehmin
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Year: 2023
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Journal: Indian Journal of Dental Research
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Results: The study investigates the influence of different time intervals and microcurrent on the biomarker IL-6 and tooth movement.
Conductive extracellular matrix-derived/chitosan methacrylate/graphene oxide-pegylated hybrid hydrogel for cell expansion
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Authors: Jaramillo, Valentina; Arévalo, Daniel Felipe; González-Hernández, Martin; Cortés, María T.; Perdomo-Arciniegas, Ana María; Cruz, Juan C.; Muñoz-Camargo, Carolina
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Year: 2024
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Journal: Frontiers in Bioengineering and Biotechnology
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Results: A hybrid hydrogel based on conductive extracellular matrix and graphene oxide shows promising results for cell expansion.
Efficacy of Two Types of Non-invasive Nerve Stimulation in the Management of Myofascial Pain Caused by Temporomandibular Joint (TMJ) Disorders
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Authors: Jha, Awanindra K.; Gupta, Sweta; Sinha, Abhishek; Tanna, Medha; Priya, Leena; Singh, Shailee; Gore, Navmi R.
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Year: 2023
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Journal: Cureus
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Results: Two types of non-invasive nerve stimulation are effective in the treatment of myofascial pain caused by temporomandibular joint disorders.
Microcurrent Therapy Mitigates Neuronal Damage and Cognitive Decline in an Alzheimer’s Disease Mouse Model: Insights into Mechanisms and Therapeutic Potential
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Authors: Kim, Eun Ho; Lee, Won Seok; Kwon, Dong Rak
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Year: 2024
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Journal: International Journal of Molecular Sciences
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Results: Microcurrent therapy reduces neuronal damage and cognitive impairment in a mouse model of Alzheimer’s disease.
